postherpetic neuralgia
Conditions
Interventions
A:Gabapentin oral plus lidocaine injection
B:Gabapentin Oral + Botulinum Toxin A100u Injection
C:Gabapentin Oral + Botulinum Toxin A200u Injection
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Posterior herpes zoster neuralgia was diagnosed; 2. Aged at least 18 years old with clear mind; 3. Numberic Rating Scales (NRS) > 4; 4. Body Mass Index (BMI) ranged from 18.5 to 24.
Exclusion criteria
Exclusion criteria: 1. Postherpetic neuralgia in head and face; 2. Severe skin lesions or infections exist in pain areas; 3. Severe abnormal coagulation function; 4. Pregnant women, pregnant women and lactating women; 5. Allergic to BoNT-A, gabapentin or lidocaine; 6. Non-PHN pain accompanied by pain that may affect the evaluation of PHN pain; 7. Complicated with severe mental illness, alcohol addiction or drug abusers; 8. Systemic neuromuscular junction diseases (such as amyotrophic lateral sclerosis, myasthenia gravis, Lambert-Eaton syndrome, etc.); 9. Severe scoliosis; 10. Aminoglycoside antibiotics and spectinomycin were used in the past two weeks; 11. Muscle relaxation drugs were used in the past 2 weeks; 12. Researchers cannot be completed for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| numerical rating scale;Self-Rating Scale of Sleep;Infrared thermography;Serum levels of NSE, PGE1 and VEGF; | — |
Countries
China
Contacts
Public ContactWen Shen
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed