stroke
Conditions
Interventions
Experimental group:mechanical thrombectomy
Control group:Intravenous thrombolysis
Sponsors
Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged at least 18 years old; 2. Ischemic stroke was clearly diagnosed clinically and caused definite neurological dysfunction (NIHSS score > 4), no coma, and the symptoms and signs of brain function damage existed for more than 1 hour, and no significant improvement was observed before treatment; 3. Within 4.5 hours or 6 hours of onset; 4. Informed consent and signature of the patient or his family members on the benefit/risk of thrombolysis. Inclusion criteria for thrombectomy: 1. Age older than 18 years; 2. Preoperative CTASPECTS score greater than 6 points; 3. Ischemic stroke caused by macrovascular occlusion; 4. Informed consent of patients.
Exclusion criteria
Exclusion criteria: Thrombolytic exclusion criteria: 1. Neurological dysfunction is very mild or rapidly improved; 2. The onset of the disease is beyond the time window or uncertain. 3. With definite epileptic seizures; 4. Cranial CT examination revealed intracranial hemorrhage, brain edema, space-occupying effect, tumors and arteriovenous malformations; clinical manifestations of subarachnoid hemorrhage (even if CT showed normal); CT showed low density > 1/3 middle cerebral artery blood supply area (patients with cerebral infarction in middle cerebral artery); 5. Previous intracranial hemorrhage, including suspicious subarachnoid hemorrhage; intracranial surgery, cranial trauma, stroke and myocardial infarction in recent 3 months; active bleeding of visceral organs such as digestive tract and urinary system in recent 3 weeks; surgical operation in recent 2 weeks; lumbar puncture or arterial puncture in recent 1 week; 6. Physical examination found evidence of active hemorrhage or trauma (such as fracture). 7. Severe heart, liver and kidney dysfunction or severe diabetes mellitus; 8. Having blood disease, bleeding tendency, coagulation disorder, platelet count 1.5; 9. Blood sugar 180 mmHg or diastolic blood pressure > 100 mmHg, or need to actively reduce blood pressure to reach the required range; 10. Pregnant women. Exclusion criteria for thrombectomy; 1) patients with severe cardiopulmonary insufficiency; 2) patients with renal failure; 3) platelets below 50*10^9.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Three-month follow-up mRS; | — |
Countries
China
Contacts
Public ContactYuan Zhengzhou
Affiliated Hospital of Southwest Medical University
Outcome results
None listed