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Diagnostic value of “Nanjing Criteria” for patients with pyrrolidine alkaloid-induced hepatic sinusoidal obstruction syndrome:a diagnoctic test.

Diagnostic value of “Nanjing Criteria” for patients with pyrrolidine alkaloid-induced hepatic sinusoidal obstruction syndrome: a diagnoctic test.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900020784
Enrollment
Unknown
Registered
2019-01-19
Start date
2019-01-16
Completion date
Unknown
Last updated
2019-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PA-HSOS

Interventions

Gold Standard:Pathologically confirmed diagnosis includes swelling, damage and shedding of hepatic sinusoidal endothelial cells in the hepatic acinus zone ?, and significant dilation and congestion of
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distention&#32
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hepatomegaly,&#32
ascites
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Sponsors

The Affiliated Drum Tower Hospital of Nanjing University Medical School
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 75 years; 2. History of PA medication, clinical emergence of abdominal distension, loss of appetite, hepatomegaly, ascites, liver dysfunction and other patients suspected PA-HSOS; 3. Signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Difficult to control the acute bleeding patients; 2. With severe coagulation dysfunction can not tolerate liver puncture; 3. With severe heart, lung, liver, renal insufficiency, hemodynamic instability need vasoactive drugs to maintain or serious Blood system diseases, bleeding tendency, etc .; 4. Data missing.

Design outcomes

Primary

MeasureTime frame
SEN, APE, ACC, AUC of ROC;

Secondary

MeasureTime frame
Peak velocity of portal vein;

Countries

China

Contacts

Public ContactZhuge Yuzheng

The Affiliated Drum Tower Hospital of Nanjing University Medical School

yuzheng9111963@aliyun.com+86 13770755008

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 23, 2026