AIDS
Conditions
Interventions
Reference treatment group:Zidovudine 300mg twice daily / tenofovir 300mg once daily + lamivudine 300mg once daily + nevirapine 200mg twice daily / efavirenz 600mg once daily
Optimized treatment group:Lopinavir/ritonavir 500mg twice daily + lamivudine 300mg once daily
Sponsors
The Fifth Affilated Hosipital Of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Asians aged 18 to 60 years old; 2. with HIV antibody positive for at least 3 months and hepatitis B surface antigen negative; 3. HIV-RNA detected in serum (PCR detection 200/µL; 5. All men and women of childbearing age must use effective contraception during the study period and within 3 months of the completion of treatment; 6. After 24 weeks of the national standard treatment regimen,HIV-RNA was < 50 copies/ml.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating woman; 2. Combined with active hepatitis; 3. Other chronic liver diseases; 4. Severe mental illness, suicide history or use of sedatives; 5. Immune-mediated disease or malignant disease, drug addiction within one year before joining the test, unable or unwilling to provide informed consent or compliance with test requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Virological breakthrough rate (HIV RNA <400 copies/mL);CD4+T lymphocyte count.; | — |
Countries
China
Contacts
Public ContactJinyu Xia
The Fifth Affilated Hosipital Of Sun Yat-sen University
Outcome results
None listed