none
Conditions
Interventions
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA I-II grade; 2. Age 18-65 years old; 3. Continuous spinal anesthesia for lower limb surgery; 4. Surgical time greater than 3 hours; 5. Voluntary participation in the trial and signing informed consent.
Exclusion criteria
Exclusion criteria: 1. Heart disease (placement pacemaker, frequent arrhythmia, atrial fibrillation, etc.); 2. Lung disease (pulmonary infection, emphysema, chronic obstructive pulmonary disease, etc.); 3. Renal function damage (BUN and / or Cr > upper limit of normal); 4. Liver function damage (ALT and / or AST > 1.5 times normal value reference range); 5. Patients with coagulopathy (PT / APTT higher than the reference limit); 6. Recent or long-term use Anticoagulation or anti-platelet aggregation drugs; 7. Preoperative hemoglobin concentration, hematocrit (Hct) is not in the normal range; 8. History of hypertension and blood pressure systolic blood pressure > 180 or diastolic blood pressure > 110mmHg two consecutive measurements did not decline; 9. Patients suffering from mental, neurological diseases, or unable to correctly express willingness; 10. Long-term use of patients with sedative analgesia, psychotropic drugs; 11. Patients with chronic alcoholism or drug abuse; 12. Spinal trauma or severe low back pain; 13. Neuromuscular disease (specifically, paraplegia, myasthenia gravis); 14. Patients with severe systemic infection or infection of the lower back; 15. Patients who refused to undergo spinal canal puncture; 16. Known difficult airways; 17. Allergic to the drugs used in this subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;Heart rate;Pulse oximetry;Bispectral index; | — |
Countries
China
Contacts
Public ContactHan Lin
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed