escharotomy and skin-grafting
Conditions
Interventions
Conventional fluid management group:The anesthesiologist in charge performs intraoperative fluid management according to clinical experience and conventional fluid management protocols (based on mean
goal directed fluid management group:The anesthesiologist in charge performed intraoperative fluid management according to a goal-directed fluid management protocol (based on cardiac index,stroke volu
Sponsors
The First Affiliated Hospital of the Army Military Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 70 years (2) Total burn area > 50% or deep II degree burn area =30%; (3) Successfully antishock (stable circulation, urine volume of 0.5-1ml/kg/h is the standard for successful resuscitation) (4) ASA III-IV (5) Patients who plan to have elective escharotomy and skin grafting; (6) Willing to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with severe cardiopulmonary disease before burn; (2) Patients with severe inhalation injury; (3) Patients with severe internal organ injury; (4) Failure of femoral artery or central vein puncture; (5) The researchers concluded other factors that were not appropriate for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative fluid inflow and outflow, blood loss, blood transfusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters, pulmonary function and blood gas parameters at 2 h, 6 h, 12 h, 24 h and 48 h after surgery;complications of cardiovascular system, respiratory system, urinary/reproductive system, blood system, endocrine system and other complications occurred 1-7 days after surgery;Mortality within 7 days after surgery; | — |
Countries
China
Contacts
Public ContactKaizhi Lu
The First Affiliated Hospital of the Army Military Medical University
Outcome results
None listed