Liver transplantation
Conditions
Interventions
ADV:extended-release tacrolimus
PRG:tacrolimus
Sponsors
Shulan (Hangzhou) Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old at enrollment; 2. Liver transplant recipients whose graft fitting criteria of donation after circulatory death; 3. Women of childbearing age promise to contraception during the trial; 4. Signing informed consent.
Exclusion criteria
Exclusion criteria: 1. Receiving other organ transplant patients other than liver transplantation; 2. Allergic to tacrolimus and other basic medications; 3. Suffering from uncontrollable local or systemic infections; 4. HIV positive recipient or donor; 5. Have severe diarrhea or vomiting, active upper gastrointestinal ulcer or malabsorption; 6. Have serious heart and lung disease; 7. Pregnant or lactating women; 8. Failure to comply with the protocol due to psychological, family, social, geographic or other reasons; 9. Participate in other clinical trials within 1 month prior to enrollment; 10. Patient refused to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of biopsy-proven acute rejection (BPAR) within 30 days after liver transplantation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dose of tacrolimus;Trough concentration of tacrolimus;The incidence of biopsy-proven acute rejection (BPAR) within 24 weeks after liver transplantation;Rate of graft loss;Patient survival rate; | — |
Countries
China
Contacts
Public ContactZheng Shusen
Shulan (Hangzhou) Hospital
Outcome results
None listed