coronary heart disease chronic renal failure
Conditions
Interventions
intervention group:iFR guided PCI
control group:CAG guided PCI
Sponsors
The Fifth Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with maintenance dialysis end-stage nephropathy aged 18 years or older; 2. Having a history of angina pectoris (CCS II-IV) with positive ischemic heart diseasepositive function test or asymptomatic evidence of myocardial ischemia in the primary blood vessel; 3. Coronary angiography showed that the stenosis of single or multiple vessels including the anterior descending branch and the right circumflex branch (the main branch whose diameter must be greater than 2.25mm) was more than 50%, and at least one lesion requiring PCI was determined by two independent interventional surgeons; 4. SYNTAX score was greater than 32, but the patient had signed and refused to undergo coronary artery bypass surgery; 5. The patient has signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Acute ST-elevation myocardial infarction or acute non-ST-elevation myocardial infarction within 6 days prior to coronary angiography; (2) Women during pregnancy; (3) Chronic complete occlusion, severe distortion or calcification of the coronary arteries,other technical reasons may affect the feasibility or accuracy of iFR testing; (4) Severe concomitant disease and life expectancy < 3 years; (5) previous coronary artery bypass grafting; (6) Contraindication of drug-eluting stents; (7)Hemodynamic instability or cardiogenic shock; (8) Unable to obtain informed consent; (9) Suspicious or definite left main artery lesion; (10) Preoperative diagnosis of active gastrointestinal bleeding,other contraindications to dual antiplatelet drugs,allergy or contraindication to heparin, contrast agent or stainless steel; (11) Participated in other interventional clinical trials (as subjects) in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| death;myocardial infarction;revascularization; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of lesions requiring coronary intervention;Radiation exposure time;Contrast dose;length of stay hospital;complications;operative successful rate;NYHA;CCS;The number of anti-angina drugs; | — |
Countries
China
Contacts
Public ContactJian Chen
The Fifth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed