gastric cancer
Conditions
Interventions
Group 1:Systemic chemotherapy plus oral chemotherapy group
Group 2:Arterial catheter infusion chemotherapy plus oral chemotherapy
Group 3:Arterial catheter infusion chemotherapy + oral chemotherapy + sodium bicarbonate
Sponsors
The Second affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients aged 18 to 75 years; 2) Ultrasound gastroscopy or imaging (CT) can diagnose potentially unresectable gastric cancer (T4a-bN2-3M0) with indications of neoadjuvant chemotherapy or transformation therapy; 3) Pathological diagnosis of gastric cancer; 4) No contraindication of chemotherapy; 5) Patients who did not undergo chemotherapy or were diagnosed for the first time.
Exclusion criteria
Exclusion criteria: 1) Those who fail to comply with the requirements of the trial, obviously violate this regimen, or change to other regimens in the course of treatment; 2) The life expectancy of patients with extensive systemic metastasis is less than 3 months; 3) Leukocyte count is less than 2*109/L and platelet count is less than 75*10^9/L; 4) Severe heart, liver and kidney diseases, unable to tolerate chemotherapy; 5) Patients without gastric cancer complications such as massive gastrointestinal bleeding and perforation need to be treated in emergency department; 6) Patients with distant metastasis (excluding group 16 lymph node metastasis); 7) Patients with other tumors, with a history of malignant tumors (excluding early primary cancers); 8) The patient himself asked to withdraw from the trial; 9) Researchers believe that patients are not suitable for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Successful conversion rate of operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;PFS; | — |
Countries
China
Contacts
Public ContactMing Chao
The Second affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed