Primary Hyperparathyroidism
Conditions
Interventions
Group 2:Ultrasound-guided Microwave Ablation
Group 2:parathyroidectomy
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Symptomatic patients; 2. Asymptomatic patients with one of the following situations: (1) An increase in serum calcium>0.25 mmol/L above the upper limit of normal; (2) Patients younger than 50 years of age; (3) Patients with a T-score <-2.5 at the lumbar spine, total hip, femoral neck, or distal 1/3 radius or those with a significant reduction in bone mineral density (BMD) and/or increased risk of fragility?fracture; (4) Patients with a reduction in creatinine clearance less than 60 ml/min; (5) Patients who were unable or unwilling to comply with observation protocols; 3.At least one parathyroid nodule clearly showed on US and accessible for MWA; 4.Increased 99 mTc-sestamibi(MIBI) radionuclide concentration in both the early and delayed phases; 5.No recurrent laryngeal nerve impairment confirmed by laryngoscopy in patients with a voice change following previous PTX.
Exclusion criteria
Exclusion criteria: 1. Abnormal coagulation function tests, such as prothrombin time longer than 18 seconds, prothrombin activity lower than 60%, and platelet count less than 60x10^9/L; 2. Intractable complications, such as cardiac insufficiency or hypertension, that could not be controlled with drugs; 3. Negative found on US and 99 mTc-sestamibi.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| iPTH;Serum calcium;Serum phosphate;ALP;Vitamin D; | — |
Contacts
Public ContactMing'an Yu
China-Japan Friendship Hospital
Outcome results
None listed