Acute cerebrovascular diseases
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Army Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged 18 years and older male and female; 2) The onset is =24 hours; 3) Patients with acute ischemic stroke and confirmed by DSA as anterior circulation vascular occlusion,complete internal occlusion of the internal carotid artery or middle cerebral artery M1 or M2 segment or anterior cerebral artery A1 segment,and NIHSSNIHSS = 2 points; 4) The patient or family members sign the informed consent form for clinical medication; 5) Intravascular endovascular treatment is proposed.
Exclusion criteria
Exclusion criteria: 1) Intracranial hemorrhage confirmed by CT or MRI; 2) Coma; 3) The nerve function quickly returns to normal; 4) Epilepsy; 5) Pregnant or lactating women; 6) Allergy to contrast agent or nickel-titanium alloy test; 7) are participating in other clinical trials; 8) Systolic blood pressure >185 mmHg, or diastolic blood pressure >110 mmHg, and oral antihypertensive drugs cannot be controlled; 9) Genetic or acquired hemorrhagic constitution, lack of anticoagulant factor; or oral anticoagulant and INR > 1.7; 10) Blood glucose 400 mg dl (22.2 mmol/L), platelets <80 * 109/L, or hematocrit < 25%; 11) The arterial tortuosity device can not reach the target blood vessel; 12) A history of bleeding in the past 1 month; 13) Carotid artery dissection, common carotid artery occlusion, arteritis; 14) mRS score = 2 points before onset; 15) Expected survival period <6 months; 16) Blood pressure = 90/60mmHg; 17) People with severe mental disorders, including dementia; 18) Patients who are allergic to Ureklin; 19) Patients and their families refused to pay for their own drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS score at 90 days;Symptomatic intracerebral hemorrhage rate within 48 h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Early Neurological Deterioration;Infarct volume;90 days of neurological improvement;Non-intracranial hemorrhagic complications;Non-hemorrhagic serious adverse events;Operational and device related complications; | — |
Countries
China
Contacts
Public ContactWu Deping
The Second Affiliated Hospital of Army Military Medical University
Outcome results
None listed