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Association between lower respiratory tract microecology and ventilator-associated pneumonia in patients with brain injury and cerebral hemorrhage

Association between lower respiratory tract microecology and ventilator-associated pneumonia in patients with brain injury and cerebral hemorrhage

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900020650
Enrollment
Unknown
Registered
2019-01-11
Start date
2019-01-07
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain injury and cerebral hemorrhage

Interventions

Probiotics group:Changle Kang (Clostridium butyricum combined viable capsule), 3 grains, po, bid
control group:placebo

Sponsors

The First Affiliated Hospital of University of Science and Technology of China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with brain injury or cerebral hemorrhage were admitted to ICU; 2. The grade of GCS was less than 8 at admission; 3. Age above 18 years old; 4. Endotracheal intubation or ventilator-assisted ventilation is expected to last more than 7 days.

Exclusion criteria

Exclusion criteria: 1. Acute and chronic liver failure, renal failure, cardiac insufficiency; 2. Severe immunodeficiency; 3. Pregnant women and lactation period; 4. Cancer patients.

Design outcomes

Primary

MeasureTime frame
Lower respiratory Microecology;Intestinal Microecology;Various immune indicators;Disease severity;Incidence of ventilator-associated pneumonia;prognosis;Respiratory metabonomics;—

Countries

China

Contacts

Public ContactPan Aijun

The First Affiliated Hospital of University of Science and Technology of China

aijunpan868@sina.com+86 13866668786

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026