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Effects of ulinastatin on cognitive dysfunction associated with intestinal flora imbalance during perioperative period

Effects of ulinastatin on cognitive dysfunction associated with intestinal flora imbalance during perioperative period

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900020641
Enrollment
Unknown
Registered
2019-01-11
Start date
2019-01-01
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative cognitive dysfunction

Interventions

Group E:Ulinastatin
Group C:none

Sponsors

Xuanwu Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 79 Years

Inclusion criteria

Inclusion criteria: Elderly patients aged 65-79 years who underwent lumbar spinal decompression and internal fixation (lumbar fusion 2-4 segments) under general anesthesia will be selected

Exclusion criteria

Exclusion criteria: 1. ASA classification >IV level; 2. Unconsciousness; 3. Mental and psychological disorders(depression); 4. Preoperative simple mental state examination (MMSE)=23; 5. Montreal cognitive test 177umol/L), active liver disease; 13. Tumor disease, acute trauma or inflammatory disease; 14. Brain tumors; 15. Epilepsy; 16. Parkinson's disease, cerebrovascular dementia, etc.; 17. Cardiovascular diseases such as myocardial infarction within 6 months; 18. Cerebrovascular diseases sunch as history of cerebral hemorrhage or cerebral embolism within 6 months or neurological sequelae after 6 months or more.

Design outcomes

Primary

MeasureTime frame
Intestinal flora spectrum;Postoperative alteration of cognitive function;—

Countries

China

Contacts

Public ContactWANG TIANLONG

Xuanwu Hospital, Capital Medical University

w_tl5595@hotmail.com+86 13910525304

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026