gout
Conditions
Interventions
1:Celery seed extract
2:vitamin C
3:starch
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 to 75 years old male, consistent with the clinical classification and diagnosis criteria for gout in 2015ACR/ELUAR; (2) uric acid value is 420 microns/L(7mg/dL); (3) obtain the consent and sign the informed consent form of the subject, or family members, or guardians, or legal agents.
Exclusion criteria
Exclusion criteria: (1) allergic constitution or allergy to research drugs; (2) the authors with acute gout arthritis in the first 2 weeks were randomly selected. (3) random 2 weeks before use or plan after the random use of glucocorticoid, anti-tb drugs (e.g., ethambutol, pyrazinamide), anticoagulants such as warfarin or other coumarin anticoagulants, than cut Lu Ding), immunosuppressants (such as loop spore fungus element, tacrolimus), azathioprine and 6-mercaptopurine, cyclophosphamide, sulfamethoxazole, methoxyl benzyl organism, theophylline, niacin, diuretics, estrogen, the uric acid metabolism of drugs; (4) patients with active stage of liver disease or abnormal liver function (ALT and AST are 3 times or more than the upper limit of normal value), and patients with impaired renal function (Cr value is higher than the upper limit of normal value); (5) patients with severe hypertension (160mmHg/100mmHg) and uncontrolled diabetes after intervention treatment; (6) secondary hyperuricemia and gout, such as hyperuricemia caused by congenital metabolic disease, bone marrow hypertrophic disease, diabetic ketoacidosis, renal failure, tumor chemotherapy and/or radiotherapy; (7) patients with serious diseases of the heart, lung and central nervous system or malignant tumors;Patients with severe complications such as hematopoietic system; (8) severe deformity of gouty arthritis in late stage; (9) have a history of alcoholism, drug abuse or drug abuse within the past 1 year; (10) brain diseases, abnormal judgment ability and mental disorders; (11) those who have participated in other clinical trials in the first three months of this study were screened; (12) other researchers consider it inappropriate to participate in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uric acid compliance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of patients with uric acid at least once to SUA<360µmol/L;Percentage of patients with uric acid <300µmol/L at thelast visit;Frequency of the percentage of patients with acute gout;body composition indexes;insulin;glucose;blood lipid level;creatinine;urea nitrogen;glutamic-pyruvic transaminase;glutamic oxalacetic transaminase;Urine pH;Uric acid excretion rate;Fatty acids; | — |
Countries
China
Contacts
Public ContactTing Zhao
Affiliated Hospital of Qingdao University
Outcome results
None listed