Postoperative Delirium and Postoperative Cognitive Dysfunction
Conditions
Interventions
Group 1:2mg/kg methylene blue diluted with normal saline into total 50 ml volume
Group 2:0.9% normal saline 50ml
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Men and women patients aged 60-80 years who plan to undergo non-cardiac and non-neurosurgical surgery under general anesthesia; 2. No methylene blue taboo; 3. All patients were screened with a Mini-Mental State Examination (MMSE), and those with scores are greater than or equal to 20; 4. The liver and kidney function are normal; 5. All patients have the ability to act in full spirit, understand and sign the informed consent, and are willing to complete the whole research process.
Exclusion criteria
Exclusion criteria: 1. The patient is allergic to methylene blue and its injection components; 2. The patient has 6-phospho-glucose dehydrogenase deficiency (vicia faba disease); 3. Recent history of administration of selective serotonin reuptake inhibitors and serotonin norepinephrine reuptake inhibitors; 4. History of major head trauma; 5. The patient has a history of drug or alcohol abuse; 6. The patient has serious mental or neurological disorders; 7. Patients with severe language, hearing and visual impairment cannot communicate; 8. Patients have serious medical diseases, such as heart failure, acute stage of myocardial infarction or respiratory failure; 9. In the last 3 months, they have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Superoxide Dismutase;Homocysteine;postoperative cognitive dysfunction; | — |
Countries
China
Contacts
Public ContactZhang Jun
Huashan Hospital, Fudan University
Outcome results
None listed