The interaction of genetic/epigenetic alterations with environmental factors in the development and progression of myopia

Conditions

myopia

Wang Y, Lin Y, Jiang D, Liu L, Lin S, He J, Liang Y, Sun B, Chen Y.

2022-09-102 citations

Association of Myopia and Genetic Variants of TGFB2-AS1 and TGFBR1 in the TGF-β Signaling Pathway: A Longitudinal Study in Chinese School-Aged Children

Linjie Liu, Juan He, Xiaoyan Lu, Yimin Yuan, Dandan Jiang et al. (9 authors)

Frontiers in Cell and Developmental Biology2021-04-285 citations

10.3389/fcell.2021.628182

Genome-Wide Association of Genetic Variants With Refraction, Axial Length, and Corneal Curvature: A Longitudinal Study of Chinese Schoolchildren

Yaoyao Lin, Yu Ding, Dandan Jiang, Chunchun Li, Xiaoqiong Huang et al. (9 authors)

Frontiers in Genetics2020-03-259 citations

10.3389/fgene.2020.00276

Interventions

Near work, outdoor activities intervention group:Nil

Control group:Nothing

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: School-age children of three primary schools in wenzhou (the baseline was grade 1 to grade 3) who had been observed and followed up for 6 years and volunteered to participate in this study.

Exclusion criteria

Exclusion criteria: Exclude high myopia, other eye diseases, no history of ocular or systemic abnormalities that may potentially affect visual function and refractive development.

Design outcomes

Primary

Measure	Time frame
Axial length;Spherical equivalent;DNA methylation;RNA methylation;Near work;Outdoor activities;SNP;	—

Countries

China

Contacts

Public ContactYanyan Chen

Wenzhou Medical University

cyy@mail.eye.ac.cn+86 13858855689

Outcome results

None listed