Allergic Rhinitis
Conditions
Interventions
underground control group:placebo
underground probiotics group:probiotics
underground vitamin D group:vitamin D
surface control group:plcebo
surface probiotics group:probiotics
surface vitamin D group:vitamin D
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) the diagnostic criteria for allergic rhinitis should meet the Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2015, Tianjin); (2) no other nasal and sinus lesions were found in the included patients except allergic rhinitis; (3) aged between 18 and 60 years; (4) the included patients should have normal understanding and communication ability, and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1) patients acute nasal and sinus infections and upper respiratory tract infections occurred in the first two weeks; 2) patients with other systemic diseases, such as heart disease, diabetes, chronic obstructive pulmonary disease, bronchiectasis, nephrotic syndrome, systemic lupus erythematosus, thyroid disease and other endocrine diseases and mental disorders; 3) pregnant or lactating women; 4) patients with malignant tumor history, HIV positive, hepatitis b surface antigen positive, syphilis positive, immune deficiency; 5) patients have used immunosuppressive agents before surgery within two months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale;Rhinoconjunctivitis Quality of Life Questionnaire;Skin Prick Test;Serum cytokines;IgE;regulatory cell;eosinocyte;Serum vitamin D; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nasal Resistance test;Nasal Provocation Test;nasal secretion cytokines; | — |
Countries
China
Contacts
Public ContactZheng Yongbo
West China Hospital, Sichuan University
Outcome results
None listed