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Mechanism and effect of macrophages and myofibroblasts in peri-tendinous adhesion.

Mechanism and effect of macrophages and myofibroblasts in peri-tendinous adhesion.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1900020566
Enrollment
Unknown
Registered
2019-01-08
Start date
2019-01-01
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

peri-tendinous adhesion

Interventions

The experimental group:Collect samples of adhesive waste tissue
The control group:The tendon at the end of anastomosis was removed

Sponsors

Shanghai Sixth People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 65-year-olds male or female; 2. Preoperative physical examination confirms tendon rupture/adhesion, requiring tendon anastomosis or tendolysis; 3. Good compliance, healthy psychological state, and able to cooperate with experimental observation; 4. Without complications(Diabetes, acute infection, hyperthyroidism, heart failure, hepatitis, nephritis). Fully informed of the purpose, method and possible discomfort of the test, and agree to participate in the test and sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Participants in other clinical trials during the last 3 months; 2. There are other serious systemic diseases and organ dysfunction; 3. pregnant women, lactating mothers, or in the near future has a bearing planning that can't take effective contraception measures; 4. apparent dysfunction of liver and kidney patients. The researchers determined that there was anything unsuitable for including.

Design outcomes

Primary

MeasureTime frame
TGF-ß1;iNOS, CD11c;CD206, Arg 1;

Secondary

MeasureTime frame
Nestin;

Countries

China

Contacts

Public ContactLiu Shen

Shanghai Sixth People's Hospital

liushensjtu@126.com+86 18930170230

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026