postoperative neurocognitive disorders
Conditions
Interventions
1:General anesthesia with tracheal intubation
2:Peripheral nerve block
Sponsors
Shunde Hospital of Guangzhou University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Patients who are scheduled to undergo total hip arthroplasty; 2) Aged over 65 years old; 3) ASA grade I to III; 4) Voluntary signature of informed consent.
Exclusion criteria
Exclusion criteria: 1) Refusal to participate in this study; 2) Communication barriers, inability to cooperate with researchers, such as language comprehension barriers, mental illness and illiteracy, unable to communicate with doctors, etc.; 3) suffering from cerebrovascular disease, dementia and Alzheimer's disease; 4) Identify/suspect persons with a history of alcohol, analgesics or other substances abuse and addiction; 5) Unstable angina pectoris and myocardial infarction occurred within 3 months; NYHA grade (> 3) of cardiac function; 6) Preoperative visit with blood pressure (> 180/110 mm Hg) (WHO-ISH hypertension guideline grade 3 hypertension); 7) Diabetic patients with diabetic complications (diabetic ketoacidosis, hypertonic coma, various infections, macroangiopathy, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic neuropathy, diabetic foot, etc.); 8) Severe abnormalities of liver and kidney function (severe abnormalities of liver function: ALT, conjugated bilirubin, AST, ALP, total bilirubin > 2 times the upper limit of normal value; severe abnormalities of kidney function: Cr clearance rate 177 umol/L); 9) Participated in other clinical trials within 3 months before being selected for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CAM-ICU; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hippocampal gyrus volume;Routine blood test;IL-6;CRP;Postoperative pain score; | — |
Countries
China
Contacts
Public ContactWu Xianping
Shunde Hospital of Guangzhou University of Traditional Chinese Medicine
Outcome results
None listed