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Study for Traditional Chinese Medicine Formula (Bu-Shen Zhu-Yun Formula) to Intervention of Kisspeptins to Regulate HPO Axis Function in the Treatment of LPD Infertility

Study for Traditional Chinese Medicine Formula (Bu-Shen Zhu-Yun Formula) to Intervention of Kisspeptins to Regulate HPO Axis Function in the Treatment of LPD Infertility

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900020496
Enrollment
Unknown
Registered
2019-01-02
Start date
2019-01-02
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Luteal Phase Deficiency

Interventions

Group 1:traditional Chinese medicine
Group 3:Chinese medicine + Conventional medicine

Sponsors

Jiangsu Province Hospital of TCM
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Luteal Phase Deficiency patient without pregnancy with normal sexual life for more than 12 months, and male sexual function and semen examination are normal; premenstrual or late menstruation, amenorrhea, or premenstrual or postmenstrual dripping, or accompanied by dysmenorrhea, premenstrual breast swelling, irritability, lumbar acid and cold; Basic sex hormone LH < 3.5miu/ml. On the 7th to 9th day after ovulation, P < 15ng/ml, or BBT high temperature phase < 10 days, the high phase is unstable; Following items could be met or not: (1) Color Doppler ultrasonography showed enlarged or polycystic ovaries on one or both sides, adenomyosis or bilateral ovarian chocolate cysts on one side; (2) Color Doppler ultrasonography showed that follicles with diameter less than 17 mm ovulated or luteinized follicles; (3) Biochemical pregnancy history; 2. Aged 20 to 40 yeas; 3. Hysterosalpingography with lipiodol showed that at least one side of the fallopian tube was unobstructed; 4. 1-2 dominant follicles were excreted by transvaginal color Doppler ultrasonography.

Exclusion criteria

Exclusion criteria: (1) Organic lesions of the genital system; (2) Uterine leiomyoma and pelvic inflammatory diseases; (3) Abnormal detection of serum immune antibodies; (4) Complication with other serious internal medicine or/and psychiatric diseases; (5) be exposed to teratogenic doses of radiation, poisons, drugs and in action.

Design outcomes

Primary

MeasureTime frame
Kisspeptins;GnRH;Women's Sex Hormone (FSH/LH/E2/T/P/PRL);3DCU;

Secondary

MeasureTime frame
the TCM syndrome sco;

Countries

China

Contacts

Public ContactHuifang Zhou

Nanjing University of Traditional Chinese Medicine

zhouhuifang2011301@163.com+86 13851858108

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026