precocious puberty
Conditions
Interventions
Case series:no
Sponsors
Shenzhen Children's Hospital
Eligibility
Sex/Gender
Female
Age
3 Years to 7.9 Years
Inclusion criteria
Inclusion criteria: IPT group inclusion criteria: 1. Girl appearing breast development before the age of 8, without signs of other sexual development, no nipple, areola pigmentation, no growth acceleration, no pubic hair / mane growth; 2. The size of the uterus and ovary is proportional to the actual age; 3. The GnRH stimulation test did not meet the Hypothalamic-pituitary-gonadal axis(HPGA) start; 4. The GnRH stimulation test confirmed the IPT girls to arrange a special follow-up weekend clinic, once every 3 months, can be completed with follow-up, that is, at least 1 year or 8 years old or diagnosed as ICPP.
Exclusion criteria
Exclusion criteria: IPT group rejection criteria: 1. CPP caused by organic lesions and peripheral precocious puberty; 2. Except for the recent accidental misuse of estrogens or the use of hormonal drugs or supplements/Chinese herbal medicines (including any of the following: royal jelly, bird's nest, Huajiao, ginseng, angelica, antler, placenta, cordyceps, hippocampus); 3. The family history of sexual precocity or a family history cannot be provided; 4. Abnormal physical birth (including births smaller than gestational age, giant children) or those who cannot provide birth history; 5. BMI exceeds the 85th percentile of the same sex with the same age. 6. The subject or parent rejects the examintion; 7. During the follow-up period, those who found organic lesions, not be able to review to the clinic on time and they will not cooperate with the urine specimens.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mono-2-ethylhexyl phthalate, MEHP;Mono(2-ethyl-5-hyduoxyhexyl)phthalate, MEHHP;Mono(2-ethyl-5oxohexyl)phthalate, MEOHP;Mono (2-ethyl-5-carboxypentyl) phthalate, MECPP;(Mono [(2-carboxymethyl)hexyl] phthalate, MCMHP;Mono-n-butyl phthalate, MBP;Monobenzyl phthalate,MBzP;Monoisopropyl Phthalate, MiPrP;Monoisobutyl phthalat e, MiBP;Mono-ethyl phthalate, MEP;mono-n-pentyl?phthalate, MnPeP;Urinary creatinine; | — |
Countries
China
Contacts
Public ContactSu Zhe
Shenzhen Children's Hospital
Outcome results
None listed