None listed
Conditions
Interventions
Group 1:sedated by dexmedetomidine
Group 2:sedated by dexmedetomidine
Sponsors
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Aged at least 65 years; undergoing total hip or knee arthroplasty, and be classified as American Society of Anesthesiologists (ASA) physical health class I–IV.
Exclusion criteria
Exclusion criteria: Contraindications to spinal anesthesia (i.e., coagulopathy, concurrent use of anticoagulants, infection at puncture site, and refusal of spinal anesthesia), patients with infectious diseases, patients with mental or language barriers, patients who had been anesthetized within the past 30 days, severe congestive heart failure (New York Heart Association, class IV) and/or severe chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease Guidelines, stages III–IV), sick sinus syndrome, severe sinus bradycardia (< 50 beats per min), and second or greater atrioventricular block without pacemaker. In addition, patients(MMSE) score < 24) and/or preoperative delirium (i.e., positive Confusion Assessment Method (CAM) result) were excluded. exhibiting cognitive impairment (i.e., a Mini-Mental State Examination (MMSE) score < 24) and/or preoperative delirium (i.e., positive Confusion Assessment Method (CAM) result) were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of the concentration of plasma IL-6 from baseline to the end surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium;The incidence of postoperative cognitive dysfunction;Change of the concentration of plasma TNF-a from baseline to the end surgery; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed