FindTrial
Sign In

A Long-term, Multicentre, Randomized Controlled Trial to Evaluated the Efficacy and Safety of Maximum Tolerated Dose of Benazepril Hydrochloride on Left Ventricular Remodeling in Patients with CHF

Whether Maximum Tolerated Dose of Benazepril Hydrochloride can Improve Left Ventricular Remodeling and Reduce Cardiovascular Events

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR1900020478
Enrollment
Unknown
Registered
2019-01-01
Start date
2013-11-30
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart failure

Interventions

Group 1:maximum tolerated dose of benazepril
Group 2:normal dosage benazepril

Sponsors

the First Affiliated Hospital of Xinjiang Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 70 years old patients with chronic congestive heart failure diagnosis; 2. echocardiography EF<40%; 3. left ventricular end diastolic diameter greater than 50 mm; 4. New York heart association function grade IIIV.

Exclusion criteria

Exclusion criteria: 1. Patients with congenital heart disease; 2. peripartum cardiomyopathy; 3. rheumatic valvular disease; 4. left ventricular dilatation caused by myocarditis; 5. patients who have received or intend to receive ICD, CRT, CRT-D and other equipment treatment; 6. patients with poor compliance; 7. acute coronary syndrome; 8. advanced cirrhosis; 9. hepatic decompensation; 10. renal decompensation (serum creatinine concentration >178 µmol/L); 11. pregnant; 12. isolated kidney; 13. kidney transplant patients.

Design outcomes

Primary

MeasureTime frame
left ventricular reverse remodeling;—

Countries

china

Contacts

Public ContactTang Baopeng

Department of Pacing Electrophysiology, the First Affiliated Hospital of Xinjiang Medical University,

tangbaopeng1111@163.com+86 13579881111

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026