unresectable hepatocellular carcinoma
Conditions
Interventions
Group 1:SBRT combined with PD-1 monoclonal antibody group
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old; 2. The patient was diagnosed as hepatocellular carcinoma for the first time; 3. Patients with locally advanced liver cancer who are unwilling or unwilling to undergo liver transplantation, hepatectomy, arterial chemoembolization and radiofrequency therapy must be diagnosed on the basis of biopsy or typical imaging findings (previous history of cirrhosis or chronic hepatitis B and hepatitis C), strict Patients with primary locally advanced HCC (single lesion diameter <6 cm) who meet the clinical diagnostic criteria for primary diagnosis and treatment of primary liver cancer (2011 version) or pathologically diagnosed or cytologically untreated without systemic chemotherapy and molecular targets To treatment; 4. Child-pugh liver function rating: grade A or better grade B (no more than 8 points); 5. ECOG PS score: 0-2; 6. The main organ function is normal, which meets the following criteria: (1) blood routine examination: HB greater than or equal to 90g/L; the ANC acuity 1.5 x 10^9/L; PLT acuity 70 x 10^9/L; (2) biochemical examination: ALB greater than or equal to 28g/L; the ALT and AST uln 5 or less; TBIL ULN 1.5 or less; Cr 1.5 or less ULN; 7. The subjects volunteered to participate in this study, signed the informed consent form, followed up with good compliance.
Exclusion criteria
Exclusion criteria: 1. Poor physical condition, PS score 3-4; 2. Grade C of liver function Child; 3. Large tumor, obvious hypersplenism, hepatic encephalopathy, massive ascites or extensive abdominal metastasis; 4. Active peptic ulcer, severe esophagogastric varices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS;OS;MRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| AFP;Liver function;Blood routine examination;Lymphocyte subsets; | — |
Countries
China
Contacts
Public ContactXue Jun
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed