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Analysis for correlation between inflammatory markers and effectiveness of treatment for periprosthetic infection after joint replacement

Analysis for correlation between inflammatory markers and effectiveness of treatment for periprosthetic infection after joint replacement

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800020440
Enrollment
Unknown
Registered
2018-12-29
Start date
2019-01-01
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periprosthetic joint infection

Interventions

Case series:none

Sponsors

The First Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1) Comply with the diagnostic criteria of PJI: 1 There is a sinus that communicates with the prosthesis; or 2 the same pathogen is isolated from the surrounding prosthetic tissue or joint fluid specimen of the affected artificial joint; or 3 meets 4 of the following 6: Increased erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) levels, ? increased synovial white blood cell count, ? increased synovial neutrophil (PMN) percentage, ? suppuration of affected joints, ? around the prosthesis Microorganisms were isolated from tissue or joint fluid samples in one culture. At a magnification of 400 times, pathological analysis of the tissues surrounding the prosthesis revealed >5 central granulocytes in five high-power fields. If less than 4 of the criteria 3 are met, joint infections around the prosthesis may exist; 2) hospitalized patients treated with periprosthetic infection after joint replacement on September 1, 2018; 3) Case data will be available.

Exclusion criteria

Exclusion criteria: 1) Patients who have not been treated for infection around the prosthesis after joint replacement in our department; 2) Those who did not sign informed consent during the perioperative period; 3) Case data cannot be checked; 4) Patients who were lost to follow-up. Patients who were hospitalized for treatment of periprosthetic infection after joint replacement were screened according to inclusion criteria and exclusion criteria. Patients were included in the study if they met the inclusion criteria and signed informed consent.

Design outcomes

Primary

MeasureTime frame
blood routine examination;erythrocyte sedimentation rate;C-Reactive Protein;procalcitonin;interleukin-6;

Countries

China

Contacts

Public ContactNing Hu

First Affiliated Hospital of Chongqing Medical University

HuNjoint@yahoo.com+86 18696761022

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 16, 2026