End-stage knee diseases
Conditions
Interventions
A:Intra-articular injection
B:Peri-articular injection
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged >18 years male or female patients; 2. Diagnosed with osteoarthritis or rheumatoid arthritis; 3. Plan to receive bilateral total knee replacement.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to any of the injectable drug ingredients or excipients; 2. Active gastrointestinal ulcers or gastrointestinal bleeding; 3. Patients with bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria, and other allergic reactions after taking aspirin or nonsteroidal anti-inflammatory drugs (including COX-2 inhibitors); 4. Knee severe varus or valgus deformity; 5. Severe liver injury (serum albumin <25g / L or Child-Pugh score =10); 6. Inflammatory bowel disease; 7. Congestive heart failure (NYHAII-IV); 8. Opioids abuse; 9. Peripheral arterial and / or cerebrovascular diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale at rest;Visual analogue scale during activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee range of motion;Operation time;Wound complications; | — |
Countries
China
Contacts
Public ContactXisheng Weng
Peking Union Medical College Hospital, Chinese Academy of Medicine Sciences
Outcome results
None listed