perioperative neurocognitive disorders
Conditions
Sponsors
Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Sign the informed consent; 2. Patients with coronary artery bypass grafting, Aged 18-75 years old, Patients of both genders; 3. NYHA class II-III; 4. ASA I to III; 5. MMSE>24; 6. Education years =6; 7. Patients can complete the TEST of Cantab.
Exclusion criteria
Exclusion criteria: 1. The drug history of gastrodin injection in the past 1 month; 2. Allergic to gastrodia, gastrodin and its excipients; 3. History of cerebrovascular disease, stroke, epilepsy, Parkinson's disease, mental illness, myasthenia gravis; 4. Unable to communicate before operation (coma, severe dementia or language disorder); 5. Brain injury or neurosurgical history and central nervous system disease; 6. Coagulation dysfunction; 7. Preoperative infection; 8. Tumor patients; 9. Severe liver dysfunction or severe renal insufficiency (dialysis before surgery); 10. Uncontrolled diabetes or hypertension; 11. Severe visual or hearing impairment; 12. Less than 6 years education; 13. Use of sedatives; 14. History of alcoholism or drug dependence; 15. Expected survival period < 24h; 16. Has received any other experimental drug treatment or participated in another interventional clinical trial within 3 months prior to screening; 17. Compliance is poor and cannot be completed according to the plan; 18. Conditions that other researchers considered unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function;Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression;Anxiety;Intubation time, CPB bypass time, duration of aorta block, length of stay in ICU, postoperative hospital stay;Cognitive function;Activity of Daily Living; | — |
Countries
China
Contacts
Public ContactQingping Wu
Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Outcome results
None listed