Kidney disease
Conditions
Interventions
Gold Standard:Pathological evaluation of renal injury according to the GSI and TBI
Laboratory index: 24-hour urinary protein quantification, urinary NAG/creatinine, urinary small molecule protein, eGFR.
MRI
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hospitalized in Beijing hospital and examined with renal biopsy; 2. Older than 18 years old; 3. 24-hour urinary protein quantification = 0.5g, or < 0.5g if accompanied by unexplained renal function reduction. eGFR < 45mL/min/1.73m2 (equivalent to stage 3b chronic kidney disease); 4. Voluntarily participate in this clinical study. Must sign written informed consent before the study.
Exclusion criteria
Exclusion criteria: 1. With acute infection, trauma or surgery within 2 weeks; 2. With mental illness or unable to follow instructions. 3. Presence of serious medical diseases such as coronary heart disease, emphysema, asthma or intolerance of breath holding due to other reasons; 4. Unable to perform MRI, such as claustrophobia, pacemaker installation or other metallic implants; 5. During pregnancy or lactation, or impending pregnancy and lactation during the study; 6. Showing poor compliance (judged by the researcher); 7. Other situations that are considered unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glomerulosclerosis index;tubulointerstitial damage index;cortical R2 values;medullary R2 values;SEN, SPE, ROC AUC; | — |
Countries
China
Contacts
Public ContactZhang Mingjun
Beijing Hospital
Outcome results
None listed