The Clincal Cure Project of Chronic Hepatitis B in China

A Real World Study of Peg-interferon Treatment for Nucleos(t)ide Analogues suppressed Chronic Hepatitis B patients with Low level Hepatitis Surface Antigen

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800020369

Enrollment

Unknown

Registered

2018-12-25

Start date

2018-12-30

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic hepatitis b

Interventions

Case series:One of three protocols: 1. Peg-IFNa-2b series

2. NAs+Peg-IFNa-2b for twelve weeks, and then Peg-IFNa-2b alone

3. NAs+Peg-IFNa-2b

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. according with the diagnosis of chronic hepatitis B in the guideline of China in 2015; 2. between 18-60 years old; 3. more than 1 year history of NAs therapy with HBsAg =1500 IU/ml, negative HBeAg and HBV DNA<100 IU/ml; 4. no contraindications of interferon and signing the consent

Exclusion criteria

Exclusion criteria: 1. Allergy to interferon; 2. ALT >10 times of ULN or total bilirubin >10 times of ULN; 3. existing or previous decompensated liver corrohsis; 4. WBC or Plt below the lower limit of normal; 5. existing severe organ injury; 6. comorbided with autoimmune diseases, psychiatric diseases, diabetes and thyroidism; 7. confirmed or suspected maligant tumors; 8. before or after transplantation; 9. using immunosuppressor; 10. pregnant or having a planned parenthood in 2 years; 11. alcohol or drug addict; 12. infected by HIV; 13. any condition that is unsuitable to interferon therapy according to the doctors' judgement.

Design outcomes

Primary

Measure	Time frame
negative conversion rate of HBsAg;seroconversion rate of HBsAg;	—

Secondary

Measure	Time frame
decent degree of HBsAg;	—

Countries

China

Contacts

Public ContactZhiliang Gao

The Third Affiliated Hospital of Sun Yat-sen University

gaozliang1962@126.com+86 18922102588

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026