Short- and long-term efficacy of near-total parathyroidectomy with autotransplantation for patients with renal hyperparathyroidism: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR1800020331

Enrollment

Unknown

Registered

2018-12-24

Start date

2019-01-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

renal hyperparathyroidism

Interventions

1:Subtotal parathyroidectomy with remnant parathyroid tissue in 1-2 normal gland size

2:Near-total parathyroidectomy with 1/2 normal gland remnant and autotransplantation with 1 normal gland autograft

3:Total parathyroidectomy with autotransplanting parathyroid tissue in 1-2 normal gland size

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with end-stage renal disease on dialysis who had an indication for surgical treatment of SHPT, fulfilling one or more of the following criteria: (1) with severe symptoms; (2) high PTH levels (> 800 pg/mL); (3) the detection of one or more enlarged parathyroid gland (>500 mm3 or diameter greater than 1 cm); (4) hypercalcemia (> 4mmol/L) and/or hyperphosphatemia (>1.94mmol/L).

Exclusion criteria

Exclusion criteria: 1. Kidney transplant patients; 2. Patients with severe skeleton deformity or bone deformities; 3. Patients with severe heart, lung, brain dysfunction and other systemic diseases; 4. Patients with severe coagulation dysfunction.

Design outcomes

Primary

Measure	Time frame
Clinical symptomatic improvement;PTH, Ca, P, ALP;Hypocalcaemia rate;requirement of vitamin D analogs;recurrence/persistent rate;time to recurrence;reoparation rate;	—

Countries

China

Contacts

Public ContactGaosong Wu

Zhongnan Hospital of Wuhan University

wugaosongtj@163.com+86 13871444606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026