Hyperuricemia
Conditions
Sponsors
the Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Male and female aged 18 to 65 years; (2) patients with a diagnosis of and no history of renal replacement therapy; (3) patients with a diagnosis of HUA [sUA levels = 420 umol/L (7 mg/dL)in male and 360 umol/L in female]; (4) No urate lowering drugs or affecting uric acid metabolism or excretion drugs were used before 1 month treatment; (5) Clinical symptoms are stable; (6) Serum uric acid of all enrolled patients was not lower than 200mmol/l.
Exclusion criteria
Exclusion criteria: (1) Patients with acute kidney injury and gout; (2) Acute and chronic infections, diseases of the immune system, diseases of the blood system, malignant tumors, and active periods of peptic ulcer; (3) Received glucocorticoid/ immunosuppression therapy; (4) Liver dysfunction (aspartate aminotransferase and/or alanine aminotransferase levels greater than two times the upper limit of institutional reference range); (5) Patients with elevated inflammatory markers for unknown reasons; (6) Patients who are allergic to medication; (7) The attending physician considered the patients unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum uric acid;high sensitivity c-reactive protein;malondialdehyde;superoxide dismutase;endothelin - 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| estimated glomerular filtration rate; | — |
Countries
China
Contacts
Public ContactXuemei Liu
the Affiliated Hospital of Qingdao University
Outcome results
None listed