osteoarthritis
Conditions
Interventions
A:aspirin 100mg bid after operation
B:Rivaroxaban 10mg qd after operation
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. primary unilateral total knee or hip arthroplasty; 2. aged 20-80 years male and female; 3. aspirin user should stop using more than 1 week; 4. patient should agree to joint the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. patient who use aspirin for tertiary prevention or double antiplatelet therapy, including acute coronary syndrome in past 3 months, post-operation of PCI or cardiac valve replacement, and other high-risk patient; 2. patient with high risk of VTE, including previous VTE history, malignant tumor, hypercoagulable state, other known states that easily lead to thrombosis and undergoing anticoagulation; 3. patient with active ulcer that can not receive aspirin therapy or has aspirin intolerance; 4. patient with other severe disease in heart, brain, lung, kidney or blood; 5. patient with gastrointestinal hemorrhage history or OB test positive =3 times after admission; 6. patient with coagulation dysfunction, trend of hemorrhage or has active hemorrhage before operation; 7. patient with systematic artery stenosis or received stent implantation for such disease; 8. patient receiving total hip arthroplasty for femoral neck fracture; 9. patient with renal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| prothrombin time;activated partial thromboplatin time;plasma thromboplastin antecedent;D-dimer;C-reaction protein;Ultrasound of deep vein of lower extremity;hemoglobin;hematocrit;platelet;type of blood transfusion;amount of blood transfusion;post-operation discomfort;circumference of both lower extremities;post-operation symptomatic VTE event;cardiovascular and cerebrovascular complication during medication; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;Heart Rate;blood oxygen saturation; | — |
Countries
China
Contacts
Public ContactXisheng Weng
Peking Union Medical College Hospital
Outcome results
None listed