Aneurysmal subarachnoid hemorrhage
Conditions
Interventions
Group 1:Deep sedation
Group 2:Light sedation
Sponsors
The First Affiliated Hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years old; 2. High level of diagnostic criteria for aneurysmal subarachnoid hemorrhage (Hunt - Hess classification III, IV); 3. Mechanical ventilation time > 72h; 4. The patient himself or his legally authorized representative is willing to provide the informed consent (ICF); 5. BMI < 35kg/m2.
Exclusion criteria
Exclusion criteria: 1. Severe brain stem failure: bilateral pupil dilation and fixation, GCS=3 score, spontaneous respiratory arrest, hypotension, cardiac arrest; 2. Epileptic status; 3. Moderate to severe renal impairment (creatinine clearance rate less than 50ml/min); 4. Allergy to opioids; 5. Drug use history of monoamine oxidase inhibitor within 14 days; 6. Neuromuscular blockers are required to improve mechanical ventilation; 7. Failure to effectively control local or systemic bacterial infection in the acute stage; 8. The end stage of chronic diseases; 9. Lactation or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of early cerebral vasospasm;The incidence of delayed cerebral ischemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| SIRS score;Difference of catecholamine;Incidence of rebleeding;Hemodynamic monitoring parameters of Picco;GCS score;Length of stay in the ICU;Length ofmechanical ventilation;Arterial blood PaCO2;28-day mortality;VAP incidence;Neurological function prognosis score (GOS) at 28 days.; | — |
Countries
China
Contacts
Public ContactXiaopeng Li
The First Affiliated Hospital of Xinjiang Medical University
Outcome results
None listed