Lung Cancer
Conditions
Interventions
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged at least 18 years old; 2. Performance Status- Eastern Cooperative Oncology Group (ECOG) 0-3; 3. Histologically or cytologic confirmed Non-small cell lung cancer, Phase IIIB or IV according to IASLC 2009; 4. Confirmed HER2 mutation by Central Laboratoryincluded PCRFISH, NGS; 5. At least one measurable lesion exists.(RECIST 1.1); 6. With no intervention in the study, patients may use pyrotinib in first or more lines; 7. Failed prior therapies.(RECIST 1.1); 8. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. There is a third interstitial fluid (such as a large amount of pleural effusion and ascites) that cannot be controlled by drainage or other methods, and the clinical treatment effect cannot be evaluated; 2. Radiotherapy, chemotherapy, surgery or other targeted therapy for non-small cell lung adenocarcinoma within 1 week prior to the study and did not progress from previous treatment; 3. The other conditions that patients are not eligible to enroll this observational study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ORR;DCR;OS; | — |
Countries
China
Contacts
Public ContactYiping Zhang
Zhejiang Cancer Hospital
Outcome results
None listed