Effect of a 2A-adrenergic receptor Gene Polymorphism on the efficacy of dexmetomidine

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR1800020255

Enrollment

Unknown

Registered

2018-12-21

Start date

2019-01-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing Lower limb surgery with epidural anesthesia

Interventions

Case series:After epidural anesthesia, dexmedetomidine was pumped 1ug/kg in 10 minutes

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 120 Patients undergoing Lower limb surgery with epidural anesthesia, ASA I-II. Aged 20-65 years,The operation is expected to take more than one hour.

Exclusion criteria

Exclusion criteria: Patient has severe liver and kidney disease;Recent use of central sedative,analgesic drugs;History of allergy to local anesthetics;Abnormal anatomical structure or infection of lumbar spine;Coagulopathy;significant arrhythmias or bradycardia;emergency operation.

Design outcomes

Primary

Measure	Time frame
The genotyping of ADRA2A C1291G;Bispectral Index value;Ramsay Sedation Scale;Heart Rate;Blood Pressure;saturation of pulse oxygen;respiratory rate;arhythmia;	—

Secondary

Measure	Time frame
Body mass index;anamnesis;	—

Countries

China

Contacts

Public ContactMa Jiahai

mjh-214@163.com+86 13656456186

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026