HIV/HCV Co infactiong
Conditions
Interventions
1:Epclusa@(Sofosbuvir/ velpatasvir)(po)
1:Genvoya@(elvitegravir 150mg/cobicistat150mg/emtricitabine200mg/tenofovir alafenamide10mg)(po)
Sponsors
Guangzhou Eighth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. aged 18 to 65 years; 2. weight more than 35 kg (no exclusion based on sex); 3. HIV-antibodies tested positive at least six months ago; HCV treatment-exposed patients must have undetectable HIV RNA within the past 12 months; 4. anti-HCV antibody or HCV RNA tested positive at least six months ago, and has tested positive for HCV RNA positive within six months of recruitment; HCV treatment-exposed patients who took PR regimen have to provide quantitative and qualitative HCR RNA test results in the period prior to treatment, 12 weeks after receiving treatment, upon termination of treatment, and 24 weeks after termination of treatment (excluding those who terminated treatment due to adverse drug reactions); 5. voluntarily agreed to sign the informed consent, participate in the study, and be able to cooperate with us for the follow-up.
Exclusion criteria
Exclusion criteria: 1. acute HIV or HCV infection at the time of recruitment; 2. opportunistic infections (according to the National AIDS Treatment Guidelines) or AIDS-related malignancy at the time of recruitment; has had opportunistic infections within 3 months of recruiment; or were in medically unstable conditions within 2 weeks of recruitment; currently taking anti-tuberculous or anti-fungal drugs; 3. test results show one of the following characteristics: alanine aminotransferase (ALT)/ aspartate amino transferase (AST) greater than10 times the upper limit of normal (ULN), total bilirubin (TB) greater than 2 times ULN, eGFR12.5Kpa; (3) APRI>2 (APRI Scoring formula: AST/ULN×100; PLT (10^9/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HIVRNA;HCVRNA; | — |
Countries
China
Contacts
Public ContactWeiping Cai
Guangzhou Eighth People's Hospital
Outcome results
None listed