Idiopathic membranous nephropathy
Conditions
Interventions
Vitamin D group:Active Vitamin D 0.5ug/day
Valsartan group:Valsartan capsule 160mg/day
Combined treatment group:Active vitamin D 0.5ug / day + valsartan capsule 160mg / day
Sponsors
The People's Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
All
Age
14 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. IMN patients aged ? 14 years old, no limit on gender and ethnicity, blood pressure normal or grade 1 hypertension; 2. renal biopsy pathological diagnosis of IMN; 3. According to the K/DIGO guidelines and Cattran risk classification: low-risk group (24-hour urine protein less than 4g, normal renal function); 4. has not received glucocorticoid therapy and other immunosuppressive agents; 5. willing to sign a written consent form; 6. willing to accept non-specific treatmen.
Exclusion criteria
Exclusion criteria: 1. Autoimmune diseases: systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid antibody syndrome, scleroderma, multiple sclerosis, idiopathic thrombocytopenia, autoimmunity cerebrospinal meningitis and so on; 2. Acute and chronic infectious diseases: hepatitis B, hepatitis C, AIDS, tuberculosis, pneumonia and inflammatory bowel disease (ulcerative colitis and Crohn disease), urinary tract infections, parasitic infections (hookworm, tapeworm, liver fluke) and so on; 3. The history of malignant tumor; 4. Allergic asthma, allergic rhinitis, allergic granulomatous vasculitis; 5. severe diabetes and uncontrollable hypertension, hypercalcemia, hyperkalemia; 6. combined pregnancy; 7. Refuse to sign a written consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total protein;albumin;25 (OH) D; | — |
Countries
China
Contacts
Public ContactKun Ye
The People's Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed