gastric cancer
Conditions
Interventions
Group 1:Use general anesthesia combined with epidural anesthesia
Group 2:Use general anesthesia
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients aged between 65 and 75 who have not received preoperative neoadjuvant therapy and who are planning to undergo laparoscopic radical gastrectomy
Exclusion criteria
Exclusion criteria: 1. Participating in another concurrent intervention trial; 2. American Society of Anesthesiologists (ASA) Physical Status Score of V; 3. Any contraindication for epidural anesthesia; 4. Patients with allergy to the study drugs; 5. Previous extensive abdominal surgery (any open or laparoscopic abdominal surgery except laparoscopic appendectomy, cholecystectomy, or hernia repair); 6. Cardiac insufficiency more than III grade (NYHA); 7. Intake of opioid analgesics, or steroids > 5 mg/day for = 7 days before surgery; 8. Long term history of intake of glucocorticoid and gastrointestinal motility drugs; 9. Under anti-depressive medication; 10. Patient with primary diabetes and impaired glucose tolerance, hyperthyroidism and hypothyroidism; 11. Severe obesity (BMI > 32) and severe malnutrition (BMI < 15); 12. History of constipation; 13. Pregnancy, lactation, or childbearing potential without using adequate contraception.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gastrointestinal function recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| occurrence of postoperative complications;postoperative hospital stays;visual analog pain scales (VAS);inflammatory factors;biochemical parameters;Arterial Blood Gas Analysis;Narcotic dosage; | — |
Countries
China
Contacts
Public ContactJian Zhang
Affiliated Hospital of Qingdao University
Outcome results
None listed