Primary Biliary Cirrhosis
Conditions
Interventions
1:Fenofibrate+UDCA
2:UDCA
Sponsors
Peking Union Medical College Hosipital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Satisfied the diagnostic criteria of PBC by the AASLDin 2000; (2) Aged 18-65 years old; (3) Clinical stage 2 and 3 (i.e. abnormal liver function and symptomatic phase); (4) Patients with abormal ALP and/or GGT after 6 months treatment of UDCA.
Exclusion criteria
Exclusion criteria: 1. Overlapped with other liver diseases (such as HBV, HCV, alcoholic cirrhosis, etc.) or serum ALT, AST more than 2 ULN; 2. decompensation of liver function (Child grade B/C); 3. combined with tumor; 4. complicated with important organ failure (such as renal insufficiency), serious infection or other serious complications; 5. pregnancy, preparation for pregnancy or pregnancy Lactation, psychiatric subjects, etc.; 6. People with a history of serious drug allergy or allergic constitution; 7. Patients with markedly elevated blood lipids (such as triglyceride > 500mg/dl) requiring lipid lowering therapy, or who have already treated by statins; 8. Participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALP; | — |
Countries
China
Contacts
Public ContactLi Wang
Peking Union Medical College Hospital
Outcome results
None listed