Grave's disease
Conditions
Interventions
1:thiamazole
2:methotrexate and thiamazole
Sponsors
Dept. of Endocrine and Metabolic Diseases,Ruijin Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: All of the patients (first diagnosed without medication or drug withdrawal for more than one yr) aged 18 to 65 yr, based on 2016 American Thyroid Association Guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis: 1. symptoms of thyrotoxicosis (heat, sweating, heart palpitations, etc.); 2. diffuse goiter without nodular formation at ultrasound; 3. raised FT4 and FT3 levels with low TSH and the presence of TRAb in the serum (5 IU/L<TRAb<30 IU/L).
Exclusion criteria
Exclusion criteria: 1. previously undergone radioiodine 131 or thyroid surgery; 2. leukopenia (defined as a white blood cell count 2.5ULM, past severe liver diseases; 5. Women in pregnancy or lactation, or men and women who plan to have babies in 2 years (obtain womens negative pregnancy test and avoid pregnant); 6. Allergic to treatment7. Encounter any conditions that would prevent the patient from adhering to protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TRAb;FT3;FT4;TSH;TPOAb;TGAb;LFT;Blood Routine; | — |
Countries
China
Contacts
Public ContactWang Shu
Ruijin Hospital Affliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed