Postoperative cognitive dysfunction
Conditions
Interventions
A: Dexmedetomidine combined with parecoxib sodium
Sponsors
The Second Affiliated Hospital of Jiaxing Medical College
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged = 65 years old; (2) can communicate normally, can cooperate with and complete cognitive function test; (3) Anesthesia that agrees with general anesthesia; (4) Elective orthopedic surgery; (5) ASA I-III; (6) Patient informed consent.
Exclusion criteria
Exclusion criteria: (1) Those with a history of allergic reactions to non-steroidal drugs; (2) Those with cerebrovascular disease or have a history of brain diseases such as cerebral infarction, stroke and coronary heart disease history, etc.; (3) long-term use of analgesics or psychotropic drugs (including opioids, non-steroidal anti-inflammatory drugs, sedatives, antidepressants) and psychotropic substance abusers in patients with chronic pain or mental and neurological diseases; (4) Preoperative liver and kidney function (alanine aminotransferase, aspartate aminotransferase, urea nitrogen, creatinine) exceeds the normal value by 2 times; (5) Simplified mental state checklist (MMSE) preoperative examination <24 points; (6) History of neurological and psychological diseases including AD, Parkinson's, psychosis, etc.; (7) active gastrointestinal ulcers; (8) Take monoamine oxidase inhibitor or antidepressant within 15 days; (9) severe hearing or visual impairment; (10) Postoperative transfer to patients with intensive care unit (ICU); (11) pregnant women or mothers; (12) Anxiety or depression patients; (13) Disagree to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction rate;Inflammatory factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Adverse reactions; | — |
Countries
China
Contacts
Public ContactJianPing Wu
The Second Affiliated Hospital of Jiaxing Medical College
Outcome results
None listed