Lung cancer
Conditions
Interventions
Case series:125I brachytherapy and IMRT
Sponsors
Affiliated Zhongshan Hospital of Dalian University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients with histologically proven NSCLC and ineligible for surgical resection; NSCLC in stages III Ato B according to the International Union Against Cancer staging system; age of patients between 18 and 80, with ECOG score =2; Lung function testFEV1=1.2L/second, or =50% expected volume.; Without Thoracic Tumor history, especially never performed Thoracic radiation previously; Urine and serum of HCG in fertile woman should be negative; White blood cell count=4×10^9/L, platelet count=100×10^9/L, s-hemoglobin=90 g/L, serum creatinine=133 umol/L, and alanine transaminase levels and prothrombin time within normal ranges.
Exclusion criteria
Exclusion criteria: Patients having received chemotherapy, radiotherapy, or other anti-tumor therapy within 3 months of study treatments; a life expectancy shorter than 6 months; pregnant or nursing patients; patients with uncontrolled serious infections. Patients with a concomitant serious illness, such as uncontrolled angina pectoris, myocardial infarction in the previous 3 months; More than grade 2 neuropathy and psychiatry;Patient has malignant pleural effusions and pericardial effusion;Metastasis in supraclavicular lymph node;patient is diagnosed as malignant tumor within 3 years, but exclude skin tumor, breast cancer cervical cancer and oral in situ cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Technical safety;Adverse event; | — |
Secondary
| Measure | Time frame |
|---|---|
| Local control rate;Overall Survival; | — |
Countries
China
Contacts
Public ContactRuoyu Wang
Affiliated Zhongshan Hospital of Dalian University
Outcome results
None listed