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Investigation of mitophagy status in the liver of patients with NAFLD

Cyanidin-3-O-glucoside alleviates hepatic steatosis, NLRP3 inflammasome activation and oxidative stress by promoting PINK1-mediated mitophagy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR1800020139
Enrollment
Unknown
Registered
2018-12-16
Start date
2016-02-01
Completion date
Unknown
Last updated
2018-12-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonalcoholic fatty liver disease

Interventions

Normal :No intervention
NAFLD:No intervention

Sponsors

College of Veterinary Medicine, Jilin University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Sign informed consent; 2. NAFLD patients were selected for treatment with bariatric surgery. Healthy lean volunteers who were undergoing select abdominal surgeries, such as herniotomy or cholecystectomy; 3. Histopathologic diagnoses of NAFLD were made in accordance with characteristic histological features.

Exclusion criteria

Exclusion criteria: Samples with necroinflammation and fibrosis were excluded. None of the patients tested positive for infection with hepatitis B virus (HBV), hepatitis C virus (HCV) or human immunodeficiency virus (HIV). Patients with other causes of chronic liver disease or patients receiving potentially hepatotoxic drugs were excluded. In addition, the included patients consumed less than 20 g of alcohol per day.

Design outcomes

Primary

MeasureTime frame
mitophagy;—

Countries

China

Contacts

Public ContactXinwei Li

College of Veterinary Medicine, Jilin University

lixinwei100@jlu.edu.cn+86 15943036079

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026