Primary nephrotic syndrome in children
Conditions
Interventions
Case series:Nil
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Aged from half to 18 years; (2) Primary nephrotic syndrome (PNS), the diagnostic criteria: massive proteinuria: 24-hour proteinuria quantification (> 50 mg/kg) or morning urine protein/creatinine (mg/mg) (> 2.0), urine protein qualitative (++-+++) three times a week; hypoproteinemia: serum albumin level was lower than that of serum albumin. 25 g/L; hyperlipidemia: serum cholesterol was higher than 5.7 mmol/L; edema of different degrees. Among the four items mentioned above, 1 and 2 were the necessary conditions for diagnosis; (3) no hormone or immunosuppressive treatment was given before inclusion in the cohort study with a clear and detailed history of drug treatment; (4) secondary nephrotic syndrome (allergic purpura, lupus, hepatitis B, diabetes mellitus, hereditary nephritis, severe infection, etc.) was excluded. Chronic kidney diseases caused by tumors, drugs and other factors.
Exclusion criteria
Exclusion criteria: 1. Exclude patients with obvious hormonal side effects, intolerance of hormones or hormonal contraindications; 2. Except for nephritic-nephrotic syndrome (NNS), which has one or more of the following four items: (1) three centrifugal uroscopy examinations of erythrocyte (> 10/HP) within two weeks and confirmed glomerulogenic hematuria; (2) repeated or persistent hypertension (> 3 collections measured at different time points) Systolic and/or diastolic blood pressures are greater than the 95th percentile of blood pressure in children and adolescents of the same sex, age and height, with the exception of glucocorticoids, etc.; (3) Renal dysfunction and exclusion of insufficient blood volume; (4) persistent hypocomplementemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prognosis after 3 years (including clinical cure, complete remission, partial remission, no remission);Analysis of SSNS, SRNS and SDNS rates and their genetic background characteristics; | — |
Secondary
| Measure | Time frame |
|---|---|
| eGFR;Urine protein / creatinine;24-hour proteinuria/body weigh;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactHaiping Yang
Children's Hospital of Chongqing Medical University
Outcome results
None listed