Hand-foot Syndrome
Conditions
Interventions
Case series:TCM
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age is greater than 18 years old, male and female; 2. Patients with grade III hand-foot syndrome caused by apatinib alone; 3. Grade III hand-foot syndrome according to NCI-CTC 5.0 standard; 4. KPS > 60; 5. The functional level of major organs meets the following criteria: 1) ANC (> 1.5 *10^9/L), PLT (> 80 *10^9/L), Hb (> 90 g/L); 2) TBIL 50 ml/min) (Cockcroft-Gault formula); 6. Subjects volunteered to join the study and signed the informed consent. Willing to and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedure.
Exclusion criteria
Exclusion criteria: 1. Those with hand-foot skin lesions or history of allergy to drugs; 2. Use other medications that can cause hand-foot syndrome at the same time, such as capecitabine, docetaxel, etc.; 3. Uncontrolled infections and metabolic diseases; 4. Coagulant function abnormality, with bleeding tendency or is treated with thrombolysis and anticoagulation; 5. Other situations that the researchers considered unsuitable for this study.ble for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of remission and the total effective rate (including symptoms remission and disappearance; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time and recurrence rate of grade III hand-foot syndrome recurred within one month after the hand-foot syndrome was reduced to grade I or the symptoms disappeared completely;Safety;completion rate of original dose intensity; | — |
Countries
China
Contacts
Public ContactQijin Shu
The First Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed