Lung cancer
Conditions
Interventions
Case series:Intratumoral injection of drug-packaging microparticles
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients must meet all the following criteria to be allowed to participate in clinical studies: 1. Patients with peripheral type IIIb and stage IV lung adenocarcinoma diagnosed by pathology or clinical examination, diameter of advanced lesion 4.0 × 10^9/L, PLT > 80 × 10^9/L; 8. Liver function: ALT and AST = 2 times ALT/AST normal value upper limit; 9. Kidney function: BUN and Cr = 1.5 times normal upper limit(ULN) or creatinine clearance = 60mL/min; 10. No other severe cardio-cerebrovascular diseases that affect treatment; 11. Patients agree to join the group and sign informed consent form.
Exclusion criteria
Exclusion criteria: Patients can not enter or continue research if they have one of the following conditions: 1. Women who are breastfeeding, pregnant or preparing for pregnancy; 2. Patients undergoing local treatment within the past four weeks; 3. Patients treated with chemotherapy or immunotherapy within the past four weeks; 4. Participants of other clinical trials within the past four weeks; 5. Patients known to be allergic to the composition of the test sample or its analogues; 6. Patients with cognitive dysfunction or have been judged by the researcher to have poor adherence to treatment; 7. Patients with contraindications of intratumoral injection with percutaneous lung puncture; 8. Other severe, acute or chronic diseases that may interfere with the interpretation of the results of the study and are judged by the researchers to be unsuitable for participation in clinical trials; 9. Those who are considered unsuitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Imaging evaluation of changes in lesion diameter; | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolism of target lesions;Immunization indicators;Tumor markers;quality of life; | — |
Countries
China
Contacts
Public ContactYi Zhang
Xuanwu Hospital, Capital Medical University
Outcome results
None listed