Chronic hepatitis B
Conditions
Interventions
Group 1:Oral supplement vitamin D 800IU per day plus pegylated interferon 180Ug per week
Group 2:pegylated interferon 180ug per week
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of chronic hepatitis B; 2. Aged 18-60 years old; 3. NAs treatment for more than 1 year, currently HBsAg=1500 IU/ml, HBeAg negative and HBV DNA<100 IU/ml; 4. No interferon treatment contraindications, willing to receive PEG-IFN treatment and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Interferon allergic; 2. ALT is greater than 10 times the ULN total bilirubin is greater than 2 times the ULN; 3. Decompensated cirrhosis; 4. Peripheral blood leukocyte count and / or platelet count is lower than the normal limit; 5. There are serious important organs such as cardiovascular, lung, kidney, brain lesions and fundus lesions; 6. Patients with autoimmune diseases, mental illness, diabetes, thyroid dysfunction (hyperactivity or low); 7. Patients diagnosed or suspected of liver cancer and other malignant tumors; 8. After organ transplantation or preparation for organ transplant; 9. Those who are using immunosuppressants; 10. Pregnancy or planned pregnancy within 2 years; 11. Alcohol or drug addicts; 12. Coinfected with HIV; 13. The competent doctor believes that there are other cases where interferon should not be used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 25 hydroxy vitamin D; | — |
Countries
China
Contacts
Public ContactMO Zhi-shuo
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed