Subclinical hypothyroidism
Conditions
Interventions
TSH 2.5~4.2mlU/L:Nil
TSH 0.27~2.5mlU/L:Nil
Sponsors
Tianjin First Central Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: (1) Aged 20-38 years; (2) Natural pregnancy (including natural pregnancy, natural cycle FET, natural cycle IUI, etc.) and single pregnancy; (3) Thyroid-related hormones in serum were measured in 1 year before pregnancy. The results ranged from TSH 0.27 to 4.2 uIU/mL, FT4 12 to 22 pmol/L, TPO-Ab < 34 IU/mL, TG-Ab < 115 IU/mL; (4) Serum thyroid-related hormones (TSH, FT4, TPO-Ab, TG-Ab) were measured in the first Central Hospital of Tianjin in early pregnancy (gestational weeks < 8 weeks). The results ranged from TSH 0.27 to 4.2 uIU/mL, FT4.12 to 22 pmol/L, TPO-Ab < 34 IU/mL, TG-Ab < 115 IU/mL.
Exclusion criteria
Exclusion criteria: (1) Previous endocrine diseases such as thyroid disease, hypothalamus or pituitary gland, diabetes mellitus, hypertension, dyslipidemia, tuberculosis or cancer, polycystic ovary syndrome, acute and chronic hepatitis or autoimmune diseases; (2) Those with severe heart, lung, kidney and liver dysfunction, abnormal coagulation function, severe infectious diseases or poor general condition; (3) Endometriosis, hysteromyoma, adenomyosis, uterine malformation, severe pelvic adhesions and hydrosalpinx; (4) TORCH was positive for IgM in either spouse; (5) Exposure to radiation, heavy metals and poisons during pregnancy, or taking drugs that affect the fetus; (6) Recurrent abortion history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| abortion; | — |
Secondary
| Measure | Time frame |
|---|---|
| premature birth;low birth weight newborn;Neonatal asphyxia;Placental abruption;Gestational hypertension; | — |
Countries
China
Contacts
Public ContactWang Yuanyuan
Tianjin First Central Hospital
Outcome results
None listed