liver failur
Conditions
Interventions
experimental group:Oral Compound of rhizoma smilacis glabra
Control group:Placebo
Sponsors
Ningbo 2nd Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years old men and women; 2. Previous diagnosis of chronic hepatitis B or post-hepatitis B cirrhosis; 3. TCM syndrome differentiation accords with: damp-heat yellowing, accumulation of epidemic toxins; manifestations: limb distress, poor acceptance, fatigue, lack of breath and laziness, head weight, abdominal distension, thick tongue coating, greasy tongue coating, pulse slippery; 4. At the same time, the diagnosis conforms to the performance criteria of HBV-ACLF syndrome: (1) Jaundice deepened rapidly, serum total bilirubin was 10 times higher than the upper limit of normal value or increased by more than 17.1 micromol/L per day; (2) Prothrombin activity (PTA) is less than 40% or INR is more than 1.5; (3) MELD-Na score < 30; 5. Compliance is good and follow-up principle can be observed.
Exclusion criteria
Exclusion criteria: 1. Complicated with severe infection (pulmonary and abdominal infection); 2. Complicated with renal impairment, creatinine value (>1.5 mg/dL) (133 umol/dL); 3. Hepatic encephalopathy grade 2 or above (West-Haven classification standard); 4. Liver malignant tumors; 5. Patients with HAV, HCV, HDV and HIV infection; 6. Alcoholic liver disease, autoimmune liver disease and hereditary metabolic liver disease; 7. Pregnant women and lactating women; 8. Those who suffer from other serious diseases affect the survival time of the patients; 9. Patients with other serious diseases affect follow-up compliance; 10. Subjects participating in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the average 24-week survival time of HBV-ACLF; | — |
Countries
China
Contacts
Public ContactQinzhi Deng
Ningbo 2nd Hospital
Outcome results
None listed