Severe acute pancreatitis
Conditions
Interventions
Group 1:Target resuscitation
Group 2:Fluid resuscitation is conducted in the speed of 15ml/kg.h, and the total volume of fluid infusion within 24h is at least 1/3 of total transfusion volume within 72h.
Group 3:Fluid resuscitation is conducted in the speed of 5-10ml/kg.h, and the volume of liquid in 24h should not exceed 4L.The primary endpoint was 28 day and 90 day mortality
Sponsors
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with moderate and severe pancreatitis within 72h; 2. Clinical manifestation: (1) Tissue perfusion: lactate >4 mmol/l; (2) Blood concentration: Hb>160 g/l or/and HCT) >0.500; (3) Hemodynamic instability, such as MAP<65mmHg.
Exclusion criteria
Exclusion criteria: 1. pregnant women; 2. aged 80 years old; 3. patients with chronic cardiac insufficiency, chronic renal insufficiency, cirrhosis, malignant tumor, or cardiac pacemaker implantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day and 90 day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| organ failures;incidence of complications;stay time of ICU;total length of stay;costs; | — |
Countries
China
Contacts
Public ContactGuo Feng
Sir Run Run Shaw Hospital affiliated to Zhejiang University
Outcome results
None listed